Podcast 776: Single-Site Blood Cultures - The Emergency Medical Minute

Podcast 776: Single-Site Blood Cultures

Contributor: Aaron Lessen, MD

Educational Pearls:

  • Traditionally, blood cultures are drawn from two separate sites despite no data to suggest this is better than drawing blood from one site
  • Recent study evaluated multi-site versus single-site blood cultures to determine if there was a difference in accuracy or contamination
  • Positive yield was 20% in the single-site year and 17% in the multi-site year
  • No difference in contamination between the two groups


Ekwall-Larson A, Yu D, Dinnétz P, Nordqvist H, Özenci V. Single-Site Sampling versus Multisite Sampling for Blood Cultures: a Retrospective Clinical Study. J Clin Microbiol. 2022;60(2):e0193521. doi:10.1128/JCM.01935-21

Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD


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