Podcast 770: Xylazine - The Emergency Medical Minute

Podcast 770: Xylazine

Contributor: Don Stader, MD

Educational Pearls:

  • Xylazine, referred to as tranq dope colloquially, is an FDA approved animal tranquilizer that is circulating in the illicit drug markets of the northeastern United states
  • It is a powerful alpha-2 agonist, similar to clonidine, and patients with xylazine overdose may present similarly to opioid overdose
  • Naloxone will not reverse the effects of xylazine and management is supportive care
  • Withdrawal symptoms from xylazine use can be treated with clonidine



Nunez J, DeJoseph ME, Gill JR. Xylazine, a Veterinary Tranquilizer, Detected in 42 Accidental Fentanyl Intoxication Deaths. Am J Forensic Med Pathol. 2021 Mar 1;42(1):9-11. doi: 10.1097/PAF.0000000000000622. PMID: 33031124.

Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD


The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at https://emergencymedicalminute.com/cme-courses/ and create an account. 

Donate to EMM today!


Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.


Stay up to date by
joining our mailing list!