Podcast 700: Analgesics for Acute Musculoskeletal Pain - The Emergency Medical Minute

Podcast 700: Analgesics for Acute Musculoskeletal Pain

Contributor: Aaron Lessen, MD

Educational Pearls:

  • Recent RCT compared pain relief in patients receiving five medications for acute musculoskeletal pain
    • Acetaminophen 1000mg/ibuprofen 400 mg 
    • Acetaminophen 1000mg/ibuprofen 800 mg
    • Acetaminophen 300 mg/codeine 30 mg
    • Acetaminophen 300mg/hydrocodone 5mg
    • Acetaminophen 325mg/oxycodone 5mg
  • No significant difference in pain relief at 1 and 2 hours between all of 5 groups


Bijur PE, Friedman BW, Irizarry E, Chang AK, Gallagher EJ. A Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department. Ann Emerg Med. 2021;77(3):345-356. doi:10.1016/j.annemergmed.2020.10.004


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