Podcast 683: Zofran vs. Haldol for Cannabinoid Hyperemesis Syndrome - The Emergency Medical Minute

Podcast 683: Zofran vs. Haldol for Cannabinoid Hyperemesis Syndrome

Contributor:  Jared Scott, MD

Educational Pearls:

  • Around 30 patients with cannabinoid hyperemesis syndrome (CHS) randomized treatment in three arms with 8mg Zofran, Haldol 0.05 mg/kg, and Haldol 0.1 mg/kg
  • Haldol arms performed better on all measures compared to Zofran
  • Extrapyramidal symptoms were significantly higher in the Haldol group than Zofran, especially the high-dose Haldol group


Ruberto AJ, Sivilotti MLA, Forrester S, Hall AK, Crawford FM, Day AG. Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial. Ann Emerg Med. 2021;77(6):613-619. doi:10.1016/j.annemergmed.2020.08.021

Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD


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