Podcast 561:  Give Bup - The Emergency Medical Minute

Podcast 561:  Give Bup

Contributor: Don Stader, MD

Educational Pearls:

  • Buprenorphine has been shown to decrease morbidity and mortality in opioid use disorder
  • Buprenorphine used in naloxone-induced withdrawals can displace naloxone at opioid receptors, leading to reduced withdrawal symptoms and lessen the chance of using after discharge
  • Patients in acute withdrawal due to naloxone after an overdose should be given Buprenorphine. Data shows that withholding Buprenorphine leads to increased mortality rates of 5% within the following month, and 10% in the following year.


  1. Herring, Andrew. “Emergency Department Medication-Assisted Treatment of Opioid Addiction.” Chcf.org, Aug. 2016, www.chcf.org/wp-content/uploads/2017/12/PDF-EDMATOpioidProtocols.pdf.
  2. D.H. Cisewski et al. Approach to buprenorphine use for opioid withdrawal treatment in the emergency setting. American Journal of Emergency Medicine 37 (2019) 143–150


Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.


Stay up to date by
joining our mailing list!